While David's focus was first on the basic molecular biophysics of a problem, he was always attuned to implications of his discoveries for human health. His approach was flavoured by an appreciation for common underlying features between these ostensibly distinct types of membrane-transport systems. His passion for hands-on do-it-yourself electrophysiology, his depth of analytical rigor, and his idiosyncratic scientific aesthetic expanded the edge of discovery in two areas: the electrical character of the Na + pump, and the molecular workings of ‘cystic fibrosis transmembrane regulator’ (CFTR), the chloride ion channel whose mutations cause cystic fibrosis. ![]() Over nearly five decades, David Christopher Gadsby pioneered biophysical research that advanced our mechanistic understanding of ion-transporting proteins in biological membranes.
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